PRESS RELEASE

Senetek PLC Launches Dedicated Pyratine-6™ Website
Online resource provides comprehensive information on
new anti-aging technology and products

Napa, CA, January 27, 2009 – Senetek PLC (OTCBB: SNKTY), a life sciences company engaged in the development of technologies that target the science of healthy aging, announced today the launch of a dedicated Pyratine-6™ website, www.Pyratine-6.com, that provides information to consumers and medical professionals about Pyratine-6, Senetek’s advanced cytokinin technology.

The website (www.Pyratine-6.com) is a comprehensive and convenient resource for information on Senetek’s anti-aging cytokinin technology and the Pyratine-6™ product line, which includes Pyratine-6™ Lotion, Crème, Foaming Cleanser, Soft Crème + 10% Vitamin C. An SPF product will be introduced in Spring 2009 to complete the Pyratine-6™ line.

Detailed sections provide site visitors with a scientific analysis of cytokinins for therapeutic applications, and present the results of a 12-week independent clinical trial that demonstrates the efficacy of Pyratine-6™ for roughness, erythema, hyperpigmentation, skin moisture, and fine wrinkles. Also featured is Senetek’s history in the development of innovative skincare technologies, including the cytokinins Kinetin and Zeatin. Additionally, a dedicated physician-only section will soon provide local resources, staff training tools and sales support to the medical community.

“The launch of the Pyratine-6™ website allows both consumers and physicians practical, reliable access to cutting-edge anti-aging information and products from Senetek,” said Frank Massino, CEO of Senetek PLC. “The straightforward design of the site echoes and supports our research-based, results-driven technology.”

About Senetek, PLC
Senetek PLC (OTCBB:SNKTY) is a life sciences company engaged in the development of breakthrough technologies that target the science of healthy aging. The company’s extensive research collaborations have resulted in a strong pipeline of patented compounds and products with broad therapeutic applications and a leading presence in dermatology. Senetek collaborates with established specialty pharmaceutical companies in the final development and marketing of its proprietary products, most recently resulting in the development of kinetin, the best-selling anti-aging product sold in the North American physician market. For more information, visit the company’s website at www.senetekplc.com.

Company Contact:
William O’Kelly
Senetek, PLC
1-707-226-3900 ext. 102

Media Contacts:
Michael Rogers/Maggie Carr
212.255.7210
michael@michaelrogerspr.com
maggie@michaelrogerspr.com