Pyratine-6® | About Pyratine-6<sup>®</sup>

The Science

Pyratine LLC forever changed skin rejuvenation science with its discovery of cytokinins for use in ameliorating the signs of aging skin. Pyratine LLC’s first developed Kinetin and Zeatin (found in the leading selling Kinerase brand). Pyratine-6 is an advanced kinetin working faster and more effectively.

Cytokinins are a class of plant growth factors which have been widely studied for their activity in plants and are well known for delaying senescence (aging) of leaves. For over a decade, Pyratine LLC has fostered scientific research internationally for their similar beneficial effect on human skin cells. Pyratine-6 is a single molecule and nature identical, providing a natural and non-chemical alternative for achieving younger looking skin.

Physicians quickly embraced the development of cytokinin-based products as revolutionary a decade ago because clinical studies showed efficacy similar to or better than prescription Renova®¹ without the associated side effects such as drying, redness, burning and peeling. Cytokinins make a genuine difference in reversing the signs of aging with virtually no side effects.²

Now, Pyratine LLC is driving cytokinin-based skin care technology to even greater levels of effectiveness with a second generation of cytokinins. Pyratine-6^® combines the safety profile of its predecessors, Kinetin and Zeatin, with unprecedented rapid delivery of benefits to significantly improve the visible signs of aging skin.

Pyratine-6^® is a cytokinin innovation fusing a tetrahydropyranyl molecule group with the Kinetin structure producing greater molecular weight and significantly more activity both in laboratory and human clinical trials. Pyratine-6^® also showed more rapid onset of action in human clinical trials³ and significantly greater improvement in improving skin roughness, reducing fine lines, wrinkles and mottled hyperpigmentation (age spots) compared to its predecessors, Kinetin and Zeatin.

Studies show cytokinin activity greatly benefits skin:

Delays the destruction of the fibroblast²Cytokinins keep fibroblasts healthy and active so they continue to produce more collagen and elastin
Significantly increases mitochondrial activity²Cytokinins’ increase in production of cellular bioenergy ensures skin’s vitality
Demonstrates antioxidant /anti-ROS activity²Cytokinins remove harmful free radicals that may be contributing to the visible signs of aging
Prevents reversion of actin patterns²Cytokinins help maintain cell structure and integrity
Delays the senescence of cells by removing cellular debris²Cytokinins help remove age-dependent cellular debris, a characteristic of aging cells and difficult to remove

Rapid-acting cytokinin Pyratine-6^® delivers even more:

Rapid onset of action — results seen in just 2 weeks³Pyratine-6^® outperforms first generation cytokinins with a significant reduction in facial redness and roughness within days

baseline

week 2

Results of a 12-week clinical trial demonstrated the cosmetic efficacy of Pyratine-6^® and statistically significant improvements were reported³
		Dr. Jerry McCullough, lead investigator in the clinical study of Pyratine-6^® stated: “In addition to the encouraging results in the treatment of photodamaged skin overall, another important finding is the significant reduction in erythema at 2 weeks and the additional reductions at weeks 4, 8, and 12. To my knowledge, this is the first report to show reduced erythema associated with use of a topical non-prescription therapeutic product.”